Right therapy, right patient, right time
From the time of diagnosis onwards, multiple factors impact on treatment selection.
Initial choice of treatment is founded on the efficacy, safety and tolerability of a DMT, given the patient’s profile. Patients may subsequently need to switch treatments because of:1,2
- Changes in disease activity
- Suboptimal responses
- Safety concerns
- Intolerable side effects / tolerability issues / change in risk tolerance
- Change in quality of life / or lifestyle, including pregnancy planning
MultiplechoiceS: Treatment sequencing
Treatment sequencing is an important and emerging concept in RRMS management1,2. It acknowledges both the heterogeneity of RRMS and the fact that as a chronic, progressive and as-yet incurable disease, patients with RRMS may need different DMTs at different times over their lifetime.
The challenge for healthcare professionals is planning the best order in which to use the available DMTs in any given patient.
Dr Matt Craner shares his views on right treatment, right patient, right choice
Dr Matt Craner is a consultant neurologist at Frimley Park Hospital, and clinical lead for the MS Trials Unit at the Nuffield Department of Clinical Neurosciences in Oxford
Sources and further reading
- Pardo G & Jones E. J Neurol 2017;264(12):2351-74.
- Grand'Maison F, et al. Curr Med Res Opin; 34(8):1419-30.
- Scolding N, et al. Pract Neurol. 2015;15(4):273-279.